Replication of gross leukemia virus in long-term cultures of rat thymomas: bioassays and electron microscopy.

Replication of Gross Leukemia Virus in Long-Term Cultures of Rat Thymomas: Bioassays and Electron Microscopy1

Two cultures of leukemic cells were established from Gross virus-induced rat thymomas and grown in vitro for 29 and 36 months. A constant and predictable virus yield was obtained that resulted in 100% induction of leukemia when cell-free materials from these cultures were assayed in susceptible animals. Electron microscopic studies of these cultures confirmed the abundance of virus and permitte...

Effects of Sodium Valproate on the Replication of Herpes Simplex Virus Type 1: An in Vitro Study

Background: Sodium valproate, an anticonvulsant drug, is reported to stimulate Human Immunodeficiency Virus type 1 and Human cytomegalovirus replication. Since epileptic patients undergoing sodium valproate therapy may suffer from various virus infections, the effect of this drug on replication of viruses especially those affecting neuronal tissues such as Herpes simplex virus type 1 is worthy ...

Infection of an established mouse bone marrow cell line (JLS-V9) with Rauscher and Moloney murine leukemia viruses.

A tell line (JLS-V9) established from the bone marrow of normal weanling HALB/c mice has been shown to be susceptible to infection with either the Rauscher or Moloney murine leu kemia viruses. The Rauscherand Moloney-virus-infected cultures were designated JLS-V10 and JLS-V11, respectively. Both infected cultures were carried for 7 months without loss of infectivity. However, more recent bioass...

Studies on the replication of African Horse Sickness Virus in two different cell line cultures

Effects of Morphine on Replication of Herpes Simplex Virus Type 1&2

Background and Aims: Several drugs are being used in treatment of HSV infection in human but still introducing an effective safe drug is desirable. Methods: We investigated the inhibitory effect of morphine on replication of HSV in vitro. Results: The results indicated that a concentration of up to 200 ug/ml morphine had a limited effect on Vero cell viability. At this concentration the growt...